Biodistribution of 99Mo in rats

Brazilian Archives of Biology and Technology

Raphael Sancho Sisley De Souza²  Bianca Da Silva Ribeiro²  Ana Letícia Almeida Dantas²  Mario Bernardo Filho¹  Bernardo Maranhão Dantas² 

[1] ,Instituto de Radioproteção e DosimetriaRio de Janeiro RJ ,Brasil

关键词: Wistar;    Molybdenum;    Nuclear Medicine;   

DOI  :  10.1590/S1516-89132008000700029

来源: SciELO

【 摘 要 】

The modification of 99Mo standard metabolism in the presence of MDP would alter the dosimetry of this radionuclide in nuclear medicine patients. Therefore, the objective of this work is to evaluate the influence of MDP in the biodistribution of 99Mo. Wistar rats were divided in two groups of six animals, being inoculated respectively 99Molibdate and 99Mo+MDP via plex ocular. The biodistribution study was carried out after 10 and 120 minutes respectively. The organs were counted with a NaI(Tl) detector. The uptake values did not present significant differences among the groups. An in vitro study through planar chromatography was carried out to determine the affinity between molybdenum and MDP. The results show that 99Mo has low affinity both to propanone and NaCl-0.9% solution. However, 99Mo in the presence of MDP presented affinity to NaCl-0.9% solution and low affinity to propanone suggesting that 99Mo was bound to MDP under the conditions of the experiment.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License