Metformin protects the skeletal muscle glycogen stores against alterations inherent to functional limitation

Brazilian Archives of Biology and Technology

Paula Lima Bosi¹  Gabriel Delfino Borges²  João Luiz Quagliotti Durigan²  Karina Maria Cancelliero²  Carlos Alberto Da Silva² 

[1] ,Universidade Metodista de Piracicaba Departamento de Fisioterapia Piracicaba SP ,Brasil

关键词: Muscle disuse;    metformin;    skeletal muscle;    rehabilitation;   

DOI  :  10.1590/S1516-89132008000200009

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the glycogen content (GC) of the rat hind limb muscles submitted to joint immobilization, either associated with metformin treatment (M, 1,4mg.ml-1) or not. In the metformin group, there was a significant increase in the GC (soleus - S 65% , white gastrocnemius - WG 30.5%, red gastrocnemius- RG31.7%, extensor digitorum longus - EDL 44%, tibialis anterior- TA 77.4%). The immobilization significantly reduced the GC (S 31.6%, WG 56.6%, RG 39.1%, ELD 41.7%, TA 45.2%) and weight (S 34.2% and ELD 27%), whereas in the group immobilized with the metformin, there was an increase in the GC of all the muscles (S 177%, WG 290%, RG 172%,ELD 47%, TA 217%), in addition to minimizing the weight loss of S (29.6%) and ELD (27.8%).

【 授权许可】

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