Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation

Brazilian Archives of Biology and Technology

Carlos Austerlitz²  Vivianne Lúcia Bormann De Souza²  Diana Maria Tavares Campos²  Cristina Kurachi¹  Vanderley Bagnato¹  Cláudio Sibata¹ 

[1] ,Centro Regional de Ciências NuclearesRecife PE ,BRAZIL

关键词: Photodynamic therapy;    hematoporphyrin;    Fricke dosimeter;    free radicals;   

DOI  :  10.1590/S1516-89132008000200006

来源: SciELO

【 摘 要 】

The vials filled with Fricke solutions were doped with increasing concentrations of Photogem®, used in photodynamic therapy. These vials were then irradiated with low-energy X-rays with doses ranging from 5 to 20 Gy. The conventional Fricke solution was also irradiated with the same doses. The concentration of ferric ions for the Fricke and doped-Fricke irradiated solutions were measured in a spectrophotometer at 220 to 340 nm. The results showed that there was an enhancement in the response of the doped-Fricke solution, which was proportional to the concentration of the photosensitizer. The use of such procedure for studying the radiosensitizing property of photosensitizers based on the production of free radicals is also discussed.

【 授权许可】

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