Glycogen levels and energy status of the liver of fasting rats with diabetes types 1 and 2

Brazilian Archives of Biology and Technology

Denise Silva De Oliveira¹  Ciomar Aparecida Bersani Amado¹  Mirian Carvalho Martini¹  Fumie Suzuki-kemmelmeier¹  Adelar Bracht¹ 

[1] ,Universidade Estadual de Maringá Laboratório de Metabolismo Hepático Maringá PR ,Brasil

关键词: Diabetes type 1;    diabetes type 2;    rats;    hepatic glycogen;    hepatic energy status;   

DOI  :  10.1590/S1516-89132007000500006

来源: SciELO

【 摘 要 】

Glycogen levels and the energy status of livers from fasting rats with diabetes types 1 and 2 were measured. After a 24 h fast, the hepatic glycogen levels of rats with diabetes1 and diabetes2 were, 18.7 and 2.6 times higher, respectively, than those of livers from the normal rats. In diabetes1 rats, the glycogen levels decreased when the fasting period was extended to 48 and 72 h. The opposite occurred with the control and diabetes2 rats. Consistently, glucose release by the perfused livers from diabetes1 rats was considerably higher during at least 60 minutes after initiating perfusion. The hepatic ATP content of diabetes1 rats was similar to that of the control rats; in diabetes2 rats, the hepatic ATP content was increased. It could be concluded that regulation of glycogen deposition and degradation in rats with diabetes1 differed markedly from that of rats with diabetes2 which, in turn, behaved similarly to normal healthy rats.

【 授权许可】

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