Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients

Brazilian Archives of Biology and Technology

Gisleine Elisa Cavalcante Da Silva²  Abdol Hakin Assef¹  Claudio Cordeiro Albino¹  Letícia De Araujo Funari Ferri¹  Gilson Tasin¹  Mirian Hideko Takahashi¹  Wilson Eik Filho¹  Roberto Barbosa Bazotte² 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia Maringá PR ,Brasil

关键词: Stevia rebaudiana (Bert) Bertoni;    stevioside;    clinical investigation;    placebo effect;   

DOI  :  10.1590/S1516-89132006000500007

来源: SciELO

【 摘 要 】

The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very low density lipoprotein, triglycerides and glucose) were performed. Stevioside did not show any clinical relevant modification in all parameters investigated. Moreover the patients did not report severe adverse effect. Thus, we can concluded that stevioside, at least in the doses employed in this study was safe.

【 授权许可】

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