Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus

Brazilian Archives of Biology and Technology

Álvaro Baptista-neto¹  Juliana Conceição Teodoro¹  Luiz Claudio Macedo Cassiano Filho¹  Alberto Colli Badino¹  Carlos Osamu Hokka¹ 

[1] ,Universidade Federal de São Carlos Departamento de Engenharia Química

关键词: Clavulanic acid;    Streptomyces clavuligerus;    continuous culture;   

DOI  :  10.1590/S1516-89132005000400012

来源: SciELO

【 摘 要 】

The aim of the present work was to compare CA production in continuous culture with and without cell recycling and in batch process by Streptomyces clavuligerus. Continuous cultivations with high cell concentration using cell recycling were performed utilizing a hollow fiber ultrafiltration module to separate cells from the filtrate broth. The continuous cultures without cell recycling and the batch cultivations were performed conventionally. The highest productivity was attained in the continuous cultivation with cell recycling (22.2 mg.L-1.h-1). The highest CA concentration was obtained in the batch process (470 mg.L-1.h-1).

【 授权许可】

CC BY-NC   
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