Actions of crude hydroalcoholic extract of Pfaffia sp on gastrointestinal tract

Brazilian Archives of Biology and Technology

Cristina Setim Freitas¹  Maria Fernanda Rodrigues De Paula¹  Lia Rieck¹  Maria Consuelo Andrade Marques¹ 

[1] ,Universidade Federal do Paraná Setor de Ciências Biológicas Departamento de FarmocologiaCuritiba PR ,Brazil

关键词: Pfaffia;    Amaranthaceae;    ulcers;    acid secretion;   

DOI  :  10.1590/S1516-89132003000300007

来源: SciELO

【 摘 要 】

The plants that compound the Pfaffia genus are used in folk medicine to treat gastric disturbances. This study examined the effects of a crude hydroalcoholic extract of Pfaffia sp on the gastrointestinal tract. Female Wistar rats were pretreated orally (p.o.) with the hydroalcoholic extract of Pfaffia (0.5, 1 and 2 g.kg-1) before the induction of ulcer with hypothermic restraint stress (HRS), ethanol (ET) or indomethacin (IND). Control animals received water (C) or ranitidine (60mg/kg) p.o. The hydroalcoholic extract of Pfaffia (0.5, 1 and 2 mg.kg-1) protected rats against HRS and ET - induced ulcers, but was not able to protect the gastric mucosa against IND - induced ulcers. When injected into the duodenal lumen, the hydroalcoholic extract of Pfaffia inhibited basal and stimulated acid secretion in pylorus-ligated rats. These results indicate that this plant has a protective action against gastric lesions of the mucosa involving the reduction of gastric acid secretion.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License