Response of the lung after pneumonectomy in alloxan diabetic rats

Brazilian Archives of Biology and Technology

Amélia Cristina Seidel²  Djalma José Fagundes¹  Neil Ferreira Novo¹  Yara Juliano¹  Hugo Meister²  Roberto Barbosa Bazotte¹ 

[1] ,Universidade Estadual de Maringá Departamento de Medicina Maringá PR ,Brazil

关键词: Experimental diabetes;    Alloxan;    Pneumonectomy;    Lung growth;    Rats;    Surgery;   

DOI  :  10.1590/S1516-89132003000200012

来源: SciELO

【 摘 要 】

In order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.

【 授权许可】

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