Trends in biological dosimetry: an overview

Brazilian Archives of Biology and Technology

Ademir Amaral¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Energia Nuclear Recife PE ,Brazil

关键词: Biodosimetry;    physical dosimetry;    biomarkers;    chromosome aberrations;   

DOI  :  10.1590/S1516-89132002000500017

来源: SciELO

【 摘 要 】

Biological dosimetry (biodosimetry) is based on investigations of induced biological effects (biomarkers) in order to correlate them with radiation dose. Among the indicators employed in biodosimetry, scoring of chromosome aberrations is the most reliable method to quantify individual exposure to ionizing radiation. The technique, applied to circulating lymphocytes, has been developed into a routine procedure to evaluate the dose in the case of real or suspected accidental exposure. Considering the radiosensitivity of lymphocytes in vitro and in vivo as being the same, the dose effect relationship obtained after in vitro irradiation of blood has been widely used, with medico-legal value, for evaluating individual radiation exposure. This report presents an overview of strengths, limitations and perspectives on biodosimetry.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License