The Influence of Ca2+ on Gluconeogenesis Stimulation by Glucagon in the Liver of Arthritic Rats

Brazilian Archives of Biology and Technology

Ana M. Kelmer-bracht¹  Zélio Fedatto-júnior¹  Emy L. Ishii-iwamoto¹  Silvana M. Caparroz-assef¹  Adelar Bracht¹ 

[1] ,Universidade Estadual de Maringá Laboratório de Metabolismo Hepático Maringá PR ,Brazil

关键词: Arthritis;    liver;    gluconeogenesis;    glucagon;   

DOI  :  10.1590/S1516-89132002000300009

来源: SciELO

【 摘 要 】

Ca2+ participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca2+ fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to glucagon and Ca2+. The experimental system was the isolated perfused rat liver. In the presence of Ca2+, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was equal to that in normal rats in absolute terms, but higher in relative terms (104.5 and 45.2%, respectively). In the absence of Ca2+, however, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was smaller in both absolute and relative terms (18.5 and 41.9%, respectively). It can be concluded that the Ca2+-dependent component of gluconeogenesis activation by glucagon is more important in arthritic than in normal rats.

【 授权许可】

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