Reticulocyte maturity indices in iron deficiency anemia

Revista Brasileira de Hematologia e Hemoterapia

Muriel Wollmann¹  Branca Maria Cerezer Gerzson¹  Vanessa Schwert¹  Rafael Weber Figuera¹  Guilherme De Oliveira Ritzel¹ 

关键词: Iron deficiency;    Reticulocytes;    Child;   

DOI  :  10.5581/1516-8484.20140009

来源: SciELO

【 摘 要 】

Objective:The aim of this study was to analyze the reticulocyte maturity indices (low, medium, and high fluorescence ratios) in iron deficient 1- to 6-year-old children, and identify the prevalence of iron deficiency anemia in this population.Methods:The present study included 39 subjects, divided into two groups: control subjects (n = 33), and subjects with iron deficiency anemia (n = 6). The results were analyzed by Student's t-test for comparison of means. Differences were considered significant when two-tailed p-value < 0.05.Results:Subjects with iron deficiency anemia presented increases in the proportion of mean (10.3 ± 4.7% vs. 6.0 ± 3.4%; p-value = 0.003), and high fluorescence reticulocytes (2.3 ± 0.87% vs. 0.9 ± 0.9%; p-value = 0.03) compared to the control group. The prevalence of anemia in this population was 15% (n = 6).Conclusion:The indices related to immaturity of reticulocytes are higher in the presence of iron deficiency, thus demonstrating a deficiency in the raw material to form hemoglobin and are, therefore, possible early markers of iron deficiency and anemia. We emphasize the need to standardize these indices for use in clinical practice and lab test results.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License