Red blood cell and leukocyte alloimmunization in patients awaiting kidneytransplantation

Revista Brasileira de Hematologia e Hemoterapia

Silvia Fernandes Ribeiro Da Silva¹  Glaucia Maria Ferreira¹  Sonia Leite Da Silva¹  T Ania Maria De Oliveira Alves¹  Ilana Farias Ribeiro¹  Thyciana Rodrigues Ribeiro¹  Maria Do Carmo Serpa Cavalcante¹ 

关键词: Kidney failure;    chronic;    Blood transfusion;    Kidney transplantation;    Antibodies;    Erythrocyte transfusion;    Cross-sectional studies;   

DOI  :  10.5581/1516-8484.20130043

来源: SciELO

【 摘 要 】

Objective: To determine the rates of red blood cell and leukocyte alloimmunization in patients with chronic kidney disease awaiting kidney transplantation. Methods: In this cross-sectional and prospective study, the serum of 393 chronic kidney disease patients on a transplant waiting list in Ceará, Northeastern Brazil were tested for red cell and leukocyte antibodies. In addition, demographic, clinical and laboratory data were collected. Results: The average age in the sample of 393 patients was 34.1 ± 14 years. Slightly more than half (208; 52.9%) were male. The average numbers of transfusions and gestations were 3.1 ± 3.3 and 1.6 ± 6, respectively. One third (33.6%) were alloimmunized: 78% with leukocyte antibodies, 9.1% with red cell antibodies and 12.9% with both. Red cell antibodies were detected in 29 cases (7.4%), 17 of whom were women, who had received more transfusions than the males (p-value < 0.0001). The most frequently detected red cell antibodies belonged to the Rh (24.1%) and Kell (13.8%) blood group systems. Leukocyte antibodies were detected in 30.5% of cases, 83 of whom were women, who had received more transfusions than the males (p-value < 0.0001) and were more reactive to panel reactive antibodies (p-value < 0.0001). The mean alloreactivity to panel reactive antibodies was 47.7 ± 31.2%. Conclusion: Chronic kidney disease patients on the transplant waiting list in Ceará, Brazil, display high rates of red cell (7.4%) and leukocyte (30.5%) alloimmunization. In this sample, alloimmunization was significantly associated with the number of transfusions and gender.

【 授权许可】

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