Epigenetic therapy in allogeneic hematopoietic stem cell transplantation

Revista Brasileira de Hematologia e Hemoterapia

Qaiser Bashir²  Basem Magdy William¹  Guillermo Garcia-manero²  Marcos De Lima¹ 

[1] ,The University of Texas MD Anderson Cancer CenterHouston TX ,USA

关键词: Hematopoietic stem cell transplantation;    DNA methyltransferase;    Leukemia;    myeloid;    Epigenesis;    genetic;    Azacitidine;    Immunologic factors;   

DOI  :  10.5581/1516-8484.20130034

来源: SciELO

【 摘 要 】

DNA methylation and other epigenetic phenomena appear to be relevant in the pathogenesis of several malignant disorders. DNA methyltransferases add methyl groups to cytosine-phosphate-guanine (CpG) islandsleading to gene promoter silencing. The DNA methyltransferases inhibitors azacitidine and decitabine have anti-tumor activity against a broad range of malignancies, but have been investigated mostly in myelodysplastic syndrome. In addition, these agents have immunomodulatory effects that are under investigation in the allogeneic stem cell transplantation scenario. Both drugs have been used in the perioperative period of allogeneic transplantations with varying degrees of success. It has been hypothesized that low dose azacitidine may increase the graftversus-leukemia effect and have a role in the maintenance of remission after allogeneic transplantation for myeloid leukemias. It is also intriguing that this favorable effect might occur while mitigating graft-versus-host disease. Here we present a review of the rapidly growing field of epigenetic manipulation using hypomethylating agents in allogeneic transplantation.

【 授权许可】

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