Chronic myelogenous leukemia: the present and the future of the TKI therapy

Revista Brasileira de Hematologia e Hemoterapia

Giuseppe Saglio¹  Carmen Fava¹ 

[1] ,University of Turin San Luigi Gonzaga Hospitao Department of Clinical and Biological SciencesTorino,Italy

关键词: Chronic myeloid leukemia;    TKi inhibitor;    resistence and intolerance;    Leucemia mieloide crônica;    inibidores de tirosino-quinases;    resistência e intolerância;   

DOI  :  10.1590/S1516-84842009000800015

来源: SciELO

【 摘 要 】

Impressive response rates and the good tolerability have allowed imatinib to become the gold standard frontline therapy for all CML patients in the early chronic phase. Optimal outcomes are attained with more than two thirds of the CML cases treated with standard dose imatinib (400 mg daily). Criteria to establish failure and suboptimal responses to imatinib have been defined. Treatment guidelines have also suggested imatinib dose escalation based on clinical assessments of disease response. However, despite all the effort to optimize therapy with imatinib, cases of real resistance exist. For imatinib resistant and intolerant cases, second generation powerful tyrosine kinase inhibitors (TKIs) have been developed and registered. Sequential kinase inhibitor therapy is used to overcome resistance however, a future strategy might be a combination therapy with different ABL kinase inhibitors in the same therapeutic scheme, used sequentially or simultaneousl.

【 授权许可】

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