Hemoglobinas variantes em doadores de sangue do Centro de Hematologia e Hemoterapia do estado do Piauí (Hemopi): conhecendo o perfil epidemiológico para construir a rede de assistência

Revista Brasileira de Hematologia e Hemoterapia

Leonardo F. Soares²  Evaldo H. Oliveira²  Iraildo B. Lima¹  José M. Silva¹  Jônathas T. Mota²  Claudia R. Bonini-domingos¹ 

[1] ,Universidade Federal do Piauí

关键词: Hemoglobin S;    blood donors;    screening;    laboratory diagnosis;    Hb variants;   

DOI  :  10.1590/S1516-84842009000600017

来源: SciELO

【 摘 要 】

The most highly prevalent inherited disease in Brazil and in the world, sickle cell anemia, is considered a public health problem. Characterized by homozygosis for the hemoglobin S gene, the individual has a range of signs and symptoms that require careful treatment. The sickle cell trait is characterized by heterozygosis for the hemoglobin S gene, however the carrier does not express the disease. In the current study we aimed at verifying the presence of the sickle cell trait in 1000 blood donors of the Hematology and Hemotherapy Center of the State of Piauí (Hemopi) in the period from October 2007 to April 2008. After analysis by alkaline and acid electrophoresis, positive cases were confirmed by molecular biology. We obtained rates of 3.4% for hemoglobin AS and 5% for hemoglobin AC, with a total frequency of 3.9% in the total of 1,000 blood donors.

【 授权许可】

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