Association of interleukin-10 levels with age of onset and duration of illness in patients with major depressive disorder

Revista Brasileira de Psiquiatria

Marta Gazal¹  Karen Jansen¹  Luciano D. Souza¹  Jean P. Oses¹  Pedro V. Magalhães¹  Ricardo Pinheiro¹  Gabriele Ghisleni¹  Luciana Quevedo¹  Manuella P. Kaster¹  Flávio Kapczinski¹  Ricardo A. Da Silva¹ 

关键词: Mood disorders;    bipolar;    mood disorders;    unipolar;    neurochemistry;    neuroimmunology;    biological markers;   

DOI  :  10.1590/1516-4446-2014-1452

来源: SciELO

【 摘 要 】

Objective: To investigate peripheral levels of interleukin-10 (IL-10) in patients with major depressive disorder (MDD) and bipolar disorder (BD) and evaluate the relationship between IL-10, age of disease onset, and duration of illness.Methods: Case-control study nested in a population-based cohort of 231 individuals (age 18-24 years) living in Pelotas, state of Rio Grande do Sul, Brazil. Participants were screened for psychopathology using the Mini-International Neuropsychiatric Interview (MINI) and the Structured Clinical Interview for DSM-IV (SCID-I). Serum IL-10 was measured using commercially available immunoassay kits.Results: Peripheral levels of IL-10 were not significantly different in individuals with MDD or BD as compared to controls. However, higher IL-10 levels were found in MDD patients with a later disease onset as compared with controls or early-onset patients. In addition, IL-10 levels correlated negatively with illness duration in the MDD group. In the BD group, age of onset and duration of illness did not correlate with IL-10 levels.Conclusion: Higher levels of IL-10 are correlated with late onset of MDD symptoms. Moreover, levels of this cytokine might decrease with disease progression, suggesting that an anti-inflammatory balance may be involved in the onset of depressive symptoms and disease progression in susceptible individuals.

【 授权许可】

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