Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-γ2 and leptin gene polymorphisms in a pedigree of subjects with bipolar disorder

Revista Brasileira de Psiquiatria

Trino Baptista¹  Ignacio Sandia¹  Erika Fernandez¹  Ligia Balzán¹  Lissette Connell¹  Euderruh Uzcátegui¹  Ana Serrano¹  Albis Pabón¹  Félix Angeles¹  Yarira Araque¹  Heidy Delgado¹  Alexy González¹  Yonathan Alviarez¹  Jose Piãero¹  Enma A. De Baptista¹ 

关键词: Bipolar disorder;    familiar hypercholesterolemia;    insulin sensitivity;    leptin;    metabolic syndrome;   

DOI  :  10.1590/1516-4446-2014-1425

来源: SciELO

【 摘 要 】

Objective:Evidence points to a high prevalence of metabolic dysfunction in bipolar disorder (BD), but few studies have evaluated the relatives of subjects with BD. We conducted a cross-sectional study in an extended family of patients with BD type I.Methods:The available relatives of the same family were interviewed (DSM-IV-R) and assessed in fasting conditions for body mass index, constituent variables of the metabolic syndrome (MS), leptin levels, insulin resistance index, and single nucleotide polymorphisms (SNPs) for the leptin receptor and promoter and PPAR-γ2 genes. The frequency of MS was compared with that recorded in the local general population.Results:Ninety-three relatives of three adults with BD were evaluated (30 aged < 18 years, 63 aged > 18 years). The frequency of MS was similar to that of the general population. Significantly higher frequencies of abnormal glucose, total and low density cholesterol (LDL-c) levels (all p < 0.05), waist circumference (p = 0.057), and leptin and insulin resistance values (in adults only) were observed in the family. Adults with the QQ genotype of the leptin receptor displayed higher LDL-c levels than carriers of the R allele.Conclusions:The associations among BD consanguinity, familial hypercholesterolemia, and leptin receptor SNPs reported herein should be replicated and extended in other pedigrees.

【 授权许可】

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