Revista Brasileira de Psiquiatria | |
Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania | |
Laura Stertz1  Gabriel Rodrigo Fries1  Bianca Wollenhaupt De Aguiar1  Bianca Pfaffenseller1  Samira S. Valvassori1  Carolina Gubert1  Camila L. Ferreira1  Morgana Moretti1  Keila M. Ceresér1  Márcia Kauer-sant'anna1  João Quevedo1  Flavio Kapczinski1  | |
关键词: Bipolar disorder; mood stabilizer; sodium butyrate; histone deacetylase; BDNF; | |
DOI : 10.1590/1516-4446-2013-1094 | |
来源: SciELO | |
【 摘 要 】
Objective: In the present study, we aimed to examine the effects of repeated D-amphetamine (AMPH) exposure, a well-accepted animal model of acute mania in bipolar disorder (BD), and histone deacetylase (HDAC) inhibitors on locomotor behavior and HDAC activity in the prefrontal cortex (PFC) and peripheral blood mononuclear cells (PBMCs) of rats. Moreover, we aimed to assess brain-derived neurotrophic factor (BDNF) protein and mRNA levels in these samples. Methods: We treated adult male Wistar rats with 2 mg/kg AMPH or saline intraperitoneally for 14 days. Between the 8th and 14th days, rats also received 47.5 mg/kg lithium (Li), 200 mg/kg sodium valproate (VPT), 2 mg/kg sodium butyrate (SB), or saline. We evaluated locomotor activity in the open-field task and assessed HDAC activity in the PFC and PBMCs, and BDNF levels in the PFC and plasma. Results: AMPH significantly increased locomotor activity, which was reversed by all drugs. This hyperactivity was associated with increased HDAC activity in the PFC, which was partially reversed by Li, VPT, and SB. No differences were found in BDNF levels. Conclusion: Repeated AMPH administration increases HDAC activity in the PFC without altering BDNF levels. The partial reversal of HDAC increase by Li, VPT, and SB may account for their ability to reverse AMPH-induced hyperactivity.
【 授权许可】
CC BY-NC
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