Animal models of neurodegenerative diseases

Revista Brasileira de Psiquiatria

Fabiola Mara Ribeiro¹  Elizabeth Ribeiro Da Silva Camargos¹  Leonardo Cruz De Souza¹  Antonio Lucio Teixeira¹ 

关键词: Neurodegenerative diseases;    Alzheimer's disease;    Parkinson's disease;    Huntington's disease;    animal models;   

DOI  :  10.1590/1516-4446-2013-1157

来源: SciELO

【 摘 要 】

The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progression. Animal models contribute to increase the knowledge on the pathophysiology of neurodegenerative diseases. These models reproduce different aspects of a given disease, as well as the histopathological lesions and its main symptoms. The purpose of this review is to present the main animal models for AD, PD, and Huntington's disease.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License