The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder

Revista Brasileira de Psiquiatria

Cristian Patrick Zeni²  Silzá Tramontina²  Thamis Aline Zeni²  Roberta Coelho²  Gabriel Pheula²  Julio Bernardi²  Ursula Maldaner²  Talita Lopes Silva²  Angélica Salatino-oliveira¹  Mara Hutz¹  Luis Augusto Rohde² 

[1] ,Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Division of Child and Adolescent Psychiatry,Brazil

关键词: BDNF;    Bipolar Disorder;    Children;    Adolescents;    Wisconsin Card Sorting Test;   

DOI  :  10.1016/j.rbp.2012.02.007

来源: SciELO

【 摘 要 】

OBJECTIVES: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). METHODS: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale - Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients' IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). RESULTS: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p = .66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). CONCLUSIONS: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data.

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