Pathophysiology of mood disorders in temporal lobe epilepsy

Revista Brasileira de Psiquiatria

Ludmyla Kandratavicius²  Rafael Naime Ruggiero²  Jaime Eduardo Hallak²  Norberto Garcia-cairasco¹  João Pereira Leite² 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Department of Neurosciences and Behavior,Brazil

关键词: Temporal Lobe Epilepsy;    Major Depression;    Interictal Dysphoria;    Psychiatric Comorbidities;    Neuropathology;    Synaptic Plasticity;    Animal Models;    Epilepsia do lobo temporal;    Depressão maior;    Disforia interictal;    Comorbidades psiquiátricas;    Neuropatologia;    Plasticidade sináptica;    Modelos animais;   

DOI  :  10.1016/j.rbp.2012.08.003

来源: SciELO

【 摘 要 】

OBJECTIVE: There is accumulating evidence that the limbic system is pathologically involved in cases of psychiatric comorbidities in temporal lobe epilepsy (TLE) patients. Our objective was to develop a conceptual framework describing how neuropathological, neurochemical and electrophysiological aspects might contribute to the development of psychiatric symptoms in TLE and the putative neurobiological mechanisms that cause mood disorders in this patient subgroup. METHODS: In this review, clinical, experimental and neuropathological findings, as well as neurochemical features of the limbic system were examined together to enhance our understanding of the association between TLE and psychiatric comorbidities. Finally, the value of animal models in epilepsy and mood disorders was discussed. CONCLUSIONS:TLE and psychiatric symptoms coexist more frequently than chance would predict. Alterations and neurotransmission disturbance among critical anatomical networks, and impaired or aberrant plastic changes might predispose patients with TLE to mood disorders. Clinical and experimental studies of the effects of seizures on behavior and electrophysiological patterns may offer a model of how limbic seizures increase the vulnerability of TLE patients to precipitants of psychiatric symptoms.

【 授权许可】

CC BY-NC   
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