Bipolar disorder and Premenstrual Syndrome or Premenstrual Dysphoric Disorder comorbidity: a systematic review

Revista Brasileira de Psiquiatria

Patricia Carvalho Cirillo²  Roberta Benitez Freitas Passos¹  Mario Cesar Do Nascimento Bevilaqua¹  Jose Ramón Rodriguez Arras López¹  Antônio Egidio Nardi² 

[1] ,Universidade Federal do Rio de Janeiro Institute of Psychiatry Laboratory of Panic & RespirationRio de Janeiro,Brazil

关键词: Bipolar Disorder;    Estrogens;    Premenstrual Syndrome;    Progesterone;    Serotonin;    Transtorno Bipolar;    Estrógenos;    Síndrome Pré-Menstrual;    Progesterona;    Serotonina;   

DOI  :  10.1016/j.rbp.2012.04.010

来源: SciELO

【 摘 要 】

OBJECTIVE: This article aims to review the comorbidity of premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) and bipolar disorder (BD), identify variables requiring further investigation and to remind physicians that special care is required for diagnosis and therapy. METHOD: A systematic review of articles published from 1987 to February 2012 was conducted in the Medline database with the following terms: (premenstrual syndrome OR premenstrual dysphoric disorder OR premenstrual) AND (bipolar OR mania OR manic). Seventeen articles were analyzed. RESULTS: PMS and PMDD were most often comorbid among BD-II patients and vice versa. Moreover, patients with PMS or PMDD also have an increased risk of having BD-I. In addition, bipolar women susceptible to hormonal changes exhibit more severe symptoms, more frequent relapses and a worse therapeutic response. CONCLUSION: Future investigations should attempt to stabilize hormonal levels through the continuous use of contraceptives to target a reduction in symptom severity. In addition, psychiatrists should note menstrual period dates and compare symptom intensity between the luteal and follicular phases. Finally, PMS and PMDD patients should be studied separately.

【 授权许可】

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