Depressive symptoms in HIV-infected patients treated with highly active antiretroviral therapy

Revista Brasileira de Psiquiatria

Marysabel Pinto Telis Silveira¹  Marília Cruz Guttier²  Cezar Arthur Tavares Pinheiro²  Tatiana Vanessa Silveira Pereira²  Ana Laura Sica Cruzeiro²  Leila Beltrami Moreira² 

[1] ,Universidade Federal do Pampa Pharmacy Course Uruguaiana,Brazil

关键词: AIDS;    CNS depressants;    drug side effects;    epidemiology;    other psychological issues;    AIDS;    depressores do SNC;    efeitos colaterais de drogas;    epidemiologia;    outras questões psicológicas;   

DOI  :  10.1590/S1516-44462012000200008

来源: SciELO

【 摘 要 】

INTRODUCTION: The prevalence of depressive disorders in HIV-infected patients ranges from 12% to 66% and is undiagnosed in 50% to 60% of these patients. Depression in HIV-infected individuals may be associated with poor antiretroviral treatment (ART) outcomes, since it may direct influence compliance. OBJECTIVE: To assess the presence of symptoms and risk factors for depression in patients on ART. METHODS: Cross-sectional study. Certified interviewers administered questionnaires and the Beck Depression Inventory (BDI), and participants' self-reported compliance to ART. Clinical and laboratory variables were obtained from clinical records. Patients with BDI > 12 were defined as depressed. RESULTS Out of the 250 patients invited to participate, 246 (98%) consented. Mean age was 41 ± 9.9 years; most were male (63%). Income ranged from 0-14 Brazilian minimum wages. AIDS (CDC stage C) had been diagnosed in 97%, and 81% were in stable immune status. One hundred ninety-one (78%) reported compliance, and 161 (68%) had undetectable viral loads. The prevalence of depressive symptoms was 32% (95% CI 26-40). In multivariate analysis, depressive symptoms were significantly associated with income (prevalence ratio [PR] = 0.85; 95% CI 0.74-0.97; p = 0.02). CONCLUSIONS: Depressive symptoms are frequent in patients on ART, and are associated with low income.

【 授权许可】

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