Molecular medicine: a path towards a personalized medicine

Revista Brasileira de Psiquiatria

Debora Marques De Miranda¹  Marcelo Mamede¹  Bruno Rezende De Souza¹  Alexandre Guimarães De Almeida Barros¹  Luiz Alexandre Magno¹  Antônio Alvim-soares Jr¹  Daniela Valadão Rosa¹  Célio José De Castro Jr¹  Leandro Malloy-diniz¹  Marcus Vinícius Gomez¹  Luiz Armando De Marco¹  Humberto Correa¹  Marco Aurélio Romano-silva¹ 

[1],Universidade Federal de Minas Gerais Faculdade de Medicina Instituto Nacional de Ciência e Tecnologia de Medicina Molecular,Brazil

关键词: Molecular Medicine;    Biomarkers;    Neuroimaging;    PET/CT;    Animal Models;    Medicina molecular;    Biomarcadores;    Neuroimagem;    PET/CT;    Modelos animais;   

DOI  :  10.1590/S1516-44462012000100015

来源: SciELO

【 摘 要 】

Psychiatric disorders are among the most common human illnesses; still, the molecular and cellular mechanisms underlying their complex pathophysiology remain to be fully elucidated. Over the past 10 years, our group has been investigating the molecular abnormalities in major signaling pathways involved in psychiatric disorders. Recent evidences obtained by the Instituto Nacional de Ciência e Tecnologia de Medicina Molecular (National Institute of Science and Technology - Molecular Medicine, INCT-MM) and others using behavioral analysis of animal models provided valuable insights into the underlying molecular alterations responsible for many complex neuropsychiatric disorders, suggesting that "defects" in critical intracellular signaling pathways have an important role in regulating neurodevelopment, as well as in pathophysiology and treatment efficacy. Resources from the INCT have allowed us to start doing research in the field of molecular imaging. Molecular imaging is a research discipline that visualizes, characterizes, and quantifies the biologic processes taking place at cellular and molecular levels in humans and other living systems through the results of image within the reality of the physiological environment. In order to recognize targets, molecular imaging applies specific instruments (e.g., PET) that enable visualization and quantification in space and in real-time of signals from molecular imaging agents. The objective of molecular medicine is to individualize treatment and improve patient care. Thus, molecular imaging is an additional tool to achieve our ultimate goal.

【 授权许可】

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