Associations between polymorphic variants of the tryptophan hydroxylase 2 gene and obsessive-compulsive disorder

Revista Brasileira de Psiquiatria

Felipe Filardi Da Rocha¹  Nathália Bueno Alvarenga¹  Naira Vassalo Lage¹  Marco Aurélio Romano-silva¹  Luiz Armando De Marco¹  Humberto Corrêa¹ 

[1] ,Universidade Federal de Minas GeraisBelo Horizonte MG ,Brazil

关键词: Psychiatry;    Obsessive-compulsive disorder;    Polymorphism;    genetic;    Tryptophan hydroxylase;    Haplotypes;    Psiquiatria;    Transtorno obsessivo-compulsivo;    Polimorfismo genético;    Triptofano hidroxilase;    Haplótipos;   

DOI  :  10.1590/S1516-44462011005000003

来源: SciELO

【 摘 要 】

OBJECTIVE: A substantial body of evidence suggests that obsessive-compulsive disorder has a genetic component, and substantial candidate genes for the disorder have been investigated through association analyses. A particular emphasis has been placed on genes related to the serotonergic system, which is likely to play an important role in the pathogenesis of obsessive-compulsive disorder. The gene for tryptophan hydroxylase 2, which is a rate limiting enzyme in serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. METHOD: Our sample consisted of 321 subjects (107 diagnosed with obsessive-compulsive disorder and 214 healthy controls), which were genotyped for eight tagSNPs (rs4448731, rs4565946, rs11179000, rs7955501, rs10506645, rs4760820, rs1487275 and rs10879357) covering the entire human tryptophan hydroxylase 2 gene. Statistical analyses were performed using UNPHASED, version 3.0.12, and Haploview ((R)). RESULTS: Single markers, genotype analysis did not show a significant genetic association with obsessive-compulsive disorder. A significant association between the T-C-T (rs4448731, rs4565946, rs10506645) and C-A-T (rs4565946, rs7955501, rs10506645) haplotypes and obsessive-compulsive disorder was observed, as well as a strong linkage disequilibrium between SNPs rs4448731 and rs4565946, and SNPs rs10506645 and 4760820. DISCUSSION: Our research has not demonstrated the existence of associations between the eight SNPs of TPH2 and obsessive-compulsive disorder. However, two LD and two haplotypes areas were demonstrated, thus suggesting that more studies in TPH2 are needed to investigate the role of tryptophan hydroxylase 2 variants in obsessive-compulsive disorder.

【 授权许可】

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