Pharmacological treatment of frontotemporal lobar degeneration: systematic review

Revista Brasileira de Psiquiatria

Maria Da Glória Portugal²  Valeska Marinho¹  Jerson Laks² 

[1] ,Universidade Federal do Rio de Janeiro Institute of Psychiatry Centre for Alzheimer's Disease and Related DisordersRio de Janeiro RJ ,Brazil

关键词: Frontotemporal dementia;    Pick's disease;    Therapeutics;    Review;    Frontotemporal lobar degeneration;    Demência frontotemporal;    Doença de Pick;    Terapêutica;    Revisão;    Degeneração lobar frontotemporal;   

DOI  :  10.1590/S1516-44462011000100016

来源: SciELO

【 摘 要 】

OBJECTIVE: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. METHOD: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal dementia" OR "fronto-temporal dementia" OR "fronto-temporal degeneration" OR "Pick's disease" OR "Pick's atrophy" OR "semantic dementia" OR "progressive aphasia" AND "pharmacotherapy" OR "treatment" OR "efficacy" OR "effects" OR "management" was performed in the Medline and Lilacs databases. Selection criteria: Quality A - randomized clinical trials. Quality B - open studies or reports of six or more cases. Quality C - reports of five or fewer cases. Two reviewers independently assessed the clinical studies. Information collected included diagnostic criteria used, sample size, duration, efficacy and tolerability measures used and results obtained. RESULTS: From the 532 studies found, 29 complied with the inclusion criteria. All studies worked with a small sample, had short duration of treatment and used non-uniform measures in evaluating efficacy and tolerability. Studies showed disparate results with respect to behavior and cognition. CONCLUSION: There is still little, and poor, evidence available for treatment of frontotemporal lobar degeneration and studies with better methodological background are needed.

【 授权许可】

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