Bipolar disorder and age-related functional impairment

Revista Brasileira de Psiquiatria

Alice Aita Cacilhas²  Pedro Vieira Da Silva Magalhães²  Keila Maria Ceresér¹  Julio Cesar Walz²  Fernanda Weyne²  Adriane Ribeiro Rosa²  Eduard Vieta¹  Flávio Kapczinski² 

[1] ,Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Molecular Psychiatry LaboratoryPorto Alegre RS ,Brazil

关键词: Bipolar disorder disability;    Functioning;    Ageing;    Controlled study;    Brazil;    Transtorno bipolar;    incapacidade;    Funcionamento;    Idade;    Estudo controlado;    Brasil;   

DOI  :  10.1590/S1516-44462009000400012

来源: SciELO

【 摘 要 】

OBJECTIVE: Although bipolar disorder is a major contributor to functional impairment worldwide, an independent impact of bipolar disorder and ageing on functioning has yet to be demonstrated. The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard. METHOD: One-hundred patients with bipolar disorder and matched controls were evaluated for disability. Age-related effects controlled for confounders were cross-sectionally evaluated. RESULTS: Patients were significantly more impaired than controls. Regression showed effects for aging in both groups. The effect, size, however, was significantly stronger in patients. CONCLUSION: Bipolar disorder was an important effect modifier of the age impact on functioning. While a longitudinal design is needed to effectively demonstrate this different impact, this study further depicts bipolar disorder as a chronic and progressively impairing illness.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License