Clinical aspects of super-refractory schizophrenia: a 6-month cohort observational study

Revista Brasileira de Psiquiatria

Jorge Henna Neto¹  Hélio Elkis¹ 

[1] ,Universidade de São Paulo Medical School Hospital das ClínicasSão Paulo SP ,Brazil

关键词: Schizophrenia;    Schizophrenia;    Treatment outcome;    Psychopathology;    Refractory period/psychological;    Esquizofrenia;    Esquizofrenia;    Resultado do tratamento;    Psicopatologia;    Período refratário psicológico;   

DOI  :  10.1590/S1516-44462007000300007

来源: SciELO

【 摘 要 】

OBJECTIVE: Approximately 30% of treatment-resistant schizophrenic patients do not fully respond to Clozapine and such patients are termed Clozapine non-responders or super-refractory schizophrenics. The aim of this study was to characterize patients with super-refractory schizophrenia according to demographic and psychopathological variables, as compared with patients with refractory schizophrenia or non-refractory subjects. METHOD: One hundred two outpatients meeting DSM-IV criteria for schizophrenia were followed-up for 6 months. Subjects were classified into 3 groups: non-refractory (n = 25), refractory (n = 43) and super-refractory (n = 34). Psychopathology was assessed by the Positive and Negative Syndrome Scale, the Schedule for Deficit Syndrome, the Calgary Depression Scale and the Quality of Life Scale. Patients were rated at 2-month intervals. RESULTS: Higher levels of severity at the disease onset as well as higher severity of positive symptoms were found to be predictive of super-refractoriness. CONCLUSIONS: The super-refractory schizophrenia patients have psychopathological predictive factors that need studies comparing brain images, genetical features and other clinical comparisons.

【 授权许可】

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