A clinical study comparing manic and mixed episodes in patients with bipolar disorder

Revista Brasileira de Psiquiatria

Ângela Maria Schwartzmann¹  José Antonio Amaral¹  Cilly Issler¹  Sheila C Caetano¹  Renata S Tamada¹  Karla Mathias De Almeida¹  Marcia Brito De Macedo Soares¹  Rodrigo Da Silva Dias¹  Cristiana C Rocca¹  Beny Lafer¹ 

[1] ,Universidade de São Paulo Medical School Department of PsychiatrySão Paulo SP ,Brazil

关键词: Comparative study;    Psychotic disorders;    Bipolar disorder;    Suicide;    attempt;    Hospitalization;    Estudo comparativo;    Transtornos psicóticos;    Transtorno bipolar;    Tentativa de suicídio;    Hospitalização;   

DOI  :  10.1590/S1516-44462006005000036

来源: SciELO

【 摘 要 】

OBJECTIVE: Mixed episodes have been described as more severe than manic episodes, especially due to their longer duration and their association with higher rates of suicide attempts, hospitalization and psychotic symptoms. The purpose of this study was to compare the severity between mixed and pure manic episodes according to DSM-IV criteria, through the evaluation of sociodemographic data and clinical characteristics. METHOD: Twenty-nine bipolar I patients presenting acute mixed episodes were compared to 20 bipolar I patients with acute manic episodes according to DSM-IV criteria. We analyzed (cross-sectionally) episode length, presence of psychotic symptoms, frequency of suicide attempts and hospitalization, Young Mania Rating Scale scores, Hamilton Depression Rating Scale scores and the Clinical Global Assessment Scale scores. RESULTS: Young Mania Rating Scale scores were higher in manic episodes than in mixed episodes. There were no differences in gender frequency, CGI scores and rates of hospitalization, suicide attempts and psychotic symptoms, when mixed and manic episodes where compared. Patients with mixed episodes were younger. CONCLUSION: In our sample, mixed states occurred at an earlier age than manic episodes. Contrary to previous reports, we did not find significant differences between manic and mixed episodes regarding severity of symptomatology, except for manic symptoms ratings, which were higher in acute manic patients. In part, this may be explained by the different criteria adopted on previous studies.

【 授权许可】

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