Nutritional genomics: a practical approach by early life conditioning with dietary phosphorus

Revista Brasileira de Zootecnia

Christopher M. Ashwell¹  Roselina Angel² 

[1] ,University Campus Box Department of Poultry Science

关键词: epigenetics;    functional genoimcs;    nutrition;    nutritional conditioning;    poultry;    aves;    condicionamento nutricional;    epigenética;    genômica funcional;    nutrição;   

DOI  :  10.1590/S1516-35982010001300030

来源: SciELO

【 摘 要 】

The recent technologies that have led to the new field of functional genomics (how the genome of an organism regulates homeostasis and responds to stimuli) are providing a clearer understanding of how organisms interact with their environment and in particular their diet. We are beginning to learn how the diet may have long-term influence on performance and health. A form of epigenetic regulation has been recently described called fetal "programming". Fueled by epidemiological data the "fetal origins" hypothesis suggests that a poor in utero environment resulting from maternal dietary or placental insufficiency may "program" susceptibility in the fetus to cardiovascular or metabolic disorders. We have observed similar apparent programming by dietary manipulation in the chicken. When birds are challenged with a diet low in phosphorus (P) for 90 hours post-hatch they obtain the ability to better utilize P later in life. This increased retention of P from the diet can partially be explained by an enduring increase in the expression of the intestine-specific Na/P cotransporter (NaPcoT) gene during programming as well as later in life when fed P restricted diets. The resulting data provide the first evidence for neonatal programming of gene expression in an oviparous species.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License