Pulmonary emphysema induced by methylphenidate: experimental study

Sao Paulo Medical Journal

Gabriel Victor Guimarães Rapello¹  Andréia Antoniolli¹  Daniel Martins Pereira¹  Gilberto Facco¹  Paulo Manuel Pêgo-fernandes¹  Rogério Pazetti¹ 

关键词: Methylphenidate;    Attention deficit disorder with hyperactivity;    Pulmonary emphysema;    Rats;    Lung;    Metilfenidato;    Transtorno do déficit de atenção com hiperatividade;    Enfisema pulmonar;    Ratos;    Pulmão;   

DOI  :  10.1590/1516-3180.2014.8470910

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate.DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university.METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm).RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48).CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.

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