Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats

Sao Paulo Medical Journal

Murat Zor¹  Serdar Goktas¹  Ibrahim Yildirim¹  Unal Orhan Zorba¹  Seref Basal¹  Bilal Firat Alp¹  Engin Kaya¹  Osman Erogul¹ 

关键词: Hypericum;    Lasers;    solid-state;    Prostatic hyperplasia;    Photochemotherapy;    Endoscopy;    Hypericum;    Lasers de estado sólido;    Hiperplasia prostática;    Fotoquimioterapia;    Endoscopia;   

DOI  :  10.1590/1516-3180-2014-1326625

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Lasers are widely used in treating symptomatic benign prostatic hyperplasia. In current practice, potassium titanyl phosphate (KTP) lasers are the most common type of laser systems used. The aim here was to evaluate the rapid effect of high-power laser systems after application of hypericin.DESIGN AND SETTING: Experimental animal study conducted in the Department of Urology, Gülhane Military Medical Academy, Ankara, Turkey, in 2012.METHODS: Sixteen rats were randomized into four groups: 120 W KTP laser + hypericin; 120 W KTP laser alone; 80 W KTP laser + hypericin; and 80 W KTP laser alone. Hypericin was given intraperitoneally two hours prior to laser applications. The laser incisions were made through the quadriceps muscle of the rats. The depth and the width of the laser incisions were evaluated histologically and recorded.RESULTS: To standardize the effects of the laser, we used the ratio of depth to width. These new values showed us the depth of the laser application per unit width. The new values acquired were evaluated statistically. Mean depth/width values were 231.6, 173.6, 214.1 and 178.9 in groups 1, 2, 3 and 4, respectively. The most notable result was that higher degrees of tissue penetration were achieved in the groups with hypericin (P < 0.05).CONCLUSIONS: The encouraging results from our preliminary study demonstrated that hypericin may improve the effects of KTP laser applications.

【 授权许可】

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