Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

Sao Paulo Medical Journal

César Augusto Alvarenga¹  José Manuel Lopes¹  João Vinagre¹  Paula Itagyba Paravidino¹  Marcelo Alvarenga¹  Adilson Prando¹  Lísias Nogueira Castilho¹  Paula Soares¹  Athanase Billis² 

[1] ,Universidade Estadual de Campinas Department of Pathology Campinas São Paulo ,Brazil

关键词: Paraganglioma;    Carcinoma;    renal cell;    Seminal vesicles;    Kidney neoplasms;    Mutation;    Paraganglioma;    Carcinoma de células renais;    Glândulas seminais;    Neoplasias renais;    Mutação;   

DOI  :  10.1590/S1516-31802012000100010

来源: SciELO

【 摘 要 】

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.

【 授权许可】

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