Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma

Sao Paulo Medical Journal

Adrienne Pratti Lucarelli²  Maria Marta Martins²  Wagner Montor¹  Vilmar Oliveira¹  Maria Antonieta Longo Galvão¹  Sebastião Piato² 

[1] ,Santa Casa de São Paulo Faculdade de Ciências Médicas Department of Gynecology and ObstetricsSão Paulo,Brazil

关键词: Cyclooxygenase 2;    Receptor;    erbB-2;    Breast neoplasms;    Carcinoma;    intraductal;    noninfiltrating;    Carcinoma;    ductal;    breast;    Ciclooxigenase 2;    Receptor erbB-2;    Neoplasias da mama;    Carcinoma intraductal não infiltrante;    Carcinoma ductal de mama;   

DOI  :  10.1590/S1516-31802011000600002

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Cyclooxygenase-2 (COX-2) and human epidermal growth factor receptor type 2 (HER-2) are associated with tumorigenesis. Studies have shown that HER-2 can regulate COX-2 expression. The aim of this study was to evaluate the correlation between COX-2 and HER-2 expression in normal breast epithelium and in ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) present in the same breast. DESIGN AND SETTING: Cross-sectional study at the Mastology Unit of the Department of Gynecology and Obstetrics, Santa Casa de Misericórdia de São Paulo Hospital. METHODS: COX-2 and HER-2 were detected using immunohistochemistry on 100 tissue fragments. HER-2 > +2 was subjected to fluorescence in situ hybridization (FISH). RESULTS: COX-2 expression was detected in 87%, 85% and 75% of IDC, DCIS and normal epithelium, respectively. HER-2 expression was detected in 34% of IDC and 34% of DCIS. COX-2 in DCIS correlated with HER-2 in IDC (P = 0.049) and DCIS (P = 0.049). COX-2 in normal epithelium correlated with HER-2 in IDC (P = 0.046) and DCIS (P = 0.046). COX-2 in IDC was not associated with HER-2 (P = 0.235). Comparison between COX-2 and HER-2 in DCIS showed that there was a statistically significant difference with regard to nuclear grades II and III and presence of comedonecrosis (P < 0.001). In IDC, there was significant expression with nuclear grades II and III and histological grade II (P < 0.001). CONCLUSIONS: Our findings provide evidence that HER-2 and COX-2 regulate each other

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