Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Sao Paulo Medical Journal

Fabiano Timbó Barbosa²  Mário Jorge Jucá²  Aldemar Araujo Castro¹  José Lira Duarte¹  Luciano Timbó Barbosa¹ 

[1] ,Universidade Federal de Alagoas Department of Clinical Surgery Maceió Alagoas ,Brazil

关键词: Hemoglobins;    Anemia;    Blood;    Blood transfusion;    Blood substitutes;    Hemoglobinas;    Anemia;    Sangue;    Transfusão de sangue;    Substitutos sanguíneos;   

DOI  :  10.1590/S1516-31802009000200008

来源: SciELO

【 摘 要 】

Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.

【 授权许可】

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