Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)

Sao Paulo Medical Journal

Renata Telles Rudge De Aquino¹  Carmen Silvia Vieitas Vergueiro¹  Maria Elisa Ruffolo Magliari¹  Thais Helena Proença De Freitas¹ 

[1] ,Santa Casa de São Paulo Faculdade de Ciências Médicas Department of Internal MedicineSão Paulo,Brazil

关键词: Drug eruptions;    Sulfasalazine;    Hypersensitivity;    Eosinophilia;    Sulfonamides;    Erupção por droga;    Sulfassalazina;    Hipersensibilidade;    Eosinofilia;    Sulfonamidas;   

DOI  :  10.1590/S1516-31802008000400006

来源: SciELO

【 摘 要 】

CONTEXT: DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature. CASE REPORT: The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License