Neutropenia, agranulocytosis and dipyrone

Sao Paulo Medical Journal

Nelson Hamerschlak¹  Alexandre Biasi Cavalcanti¹ 

[1] ,Instituto Israelita de Ensino e Pesquisa Albert Einstein Oncology & Hematology ProgramSão Paulo ,Brazil

关键词: Agranulocytosis;    Neutropenia;    Dipyrone;    Incidence;    Case-control studies;    Agranulocitose;    Neutropenia;    Dipirona;    Incidência;    Estudos de casos e controles;   

DOI  :  10.1590/S1516-31802005000500009

来源: SciELO

【 摘 要 】

CONTEXT: Neutropenia and agranulocytosis may be defined as granulocyte counts of less than 1,500/mm³ and 500/mm³, respectively. Agranulocytosis is a rare and serious disease often caused by drugs. Its mortality rate is around 10%. The most common manifestations are infections such as tonsillitis, pharyngitis, stomatitis or pneumonia. Although dipyrone is one of the drugs known to be associated with agranulocytosis, the strength of the association has been a matter of much debate. Moreover, alternative analgesic and antipyretic agents are not devoid of serious side effects. CONCLUSIONS: It is therefore necessary to establish the incidence of agranulocytosis in Latin America and the role of dipyrone. The ongoing LATIN Study is a multicenter international case-control study that will provide answers for these questions.

【 授权许可】

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