Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions

Sao Paulo Medical Journal

Sérgio Luiz Ramin¹  Waldir Antonio Tognola¹  Antonio Ronaldo Spotti¹ 

[1] ,Faculdade de Medicina de São José do Rio Preto Department of Neurological Sciences São José do Rio Preto São Paulo ,Brazil

关键词: Proton;    Spectroscopy;    Magnetic resonance;    Brain;    Espectroscopia de prótons;    Ressonância magnética;    Encéfalo;   

DOI  :  10.1590/S1516-31802003000600008

来源: SciELO

【 摘 要 】

CONTEXT: Proton spectroscopy has been recognized as a safe and noninvasive diagnostic method that, coupled with magnetic resonance imaging techniques, allows for the correlation of anatomical and physiological changes in the metabolic and biochemical processes occurring within previously-determined volumes in the brain. There are two methods of proton magnetic resonance spectroscopy: single voxel and chemical shift imaging OBJECTIVE: The present work focused on the clinical applications of proton magnetic resonance spectroscopy in patients with brain lesions. CONCLUSIONS: In vivo proton spectroscopy allows the detection of certain metabolites in brain tissue, such as N-acetyl aspartate, creatine, choline, myoinositol, amino acids and lipids, among others. N-acetyl aspartate is a neuronal marker and, as such, its concentration will decrease in the presence of aggression to the brain. Choline increase is the main indicator of neoplastic diseases. Myoinositol is raised in patients with Alzheimer's disease. Amino acids are encountered in brain abscesses. The presence of lipids is related to necrotic processes.

【 授权许可】

CC BY   
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