Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy

Sao Paulo Medical Journal

Silvia Daher¹  Flavia Fonseca¹  Roseane Mattar¹  Chloe Camba Musatti¹  Maria Gerbase De Lima¹ 

[1] ,Universidade Federal de São Paulo EPM Pediatrics DepartmentSão Paulo,Brazil

关键词: Mixed lymphocyte culture test;    Pregnancy;    Habitual abortion;   

DOI  :  10.1590/S1516-31801997000400006

来源: SciELO

【 摘 要 】

INTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.

【 授权许可】

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