Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Sao Paulo Medical Journal

Eliane Pedra Dias¹  José Maria Pinto Barcelos¹  Maria Evangelina Ferreira Fonseca¹  Nédia Gomes Da Silva Basso¹ 

[1] ,UFF Pathology Department

关键词: Congenital Papilloma;    HPV;    Papillomatosis;   

DOI  :  10.1590/S1516-31801995000400007

来源: SciELO

【 摘 要 】

The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.

【 授权许可】

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