期刊论文详细信息
Sao Paulo Medical Journal
Pathogenesis of chronic Chagas' myocarditis
Marcos A. Rossi1 
[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Department of PathologySão Paulo,Brazil
关键词: Myocarditis;    Chagas's disease;   
DOI  :  10.1590/S1516-31801995000200004
来源: SciELO
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【 摘 要 】

The pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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