In vitro biomineralization of a novel hydroxyapatite/superhydrophilic multiwalled carbon nanotube nanocomposite using simulated body fluids

Materials Research

Marcele Florencio Neves²  Tayra Rodrigues Brazil²  Eduardo Silva Soares¹  Evaldo Jose Corat¹  Fernanda Roberta Marciano²  Anderson Oliveira Lobo² 

[1] ,Universidade do Vale do Paraiba Institute of Research and Development Laboratory of Biomedical NanotechnologySão José dos Campos SP ,Brazil

关键词: biomineralization;    carbon nanotubes;    superhydrophilic;    nanohydroxyapatite;    SBF and characterization techniques;   

DOI  :  10.1590/S1516-14392013005000038

来源: SciELO

【 摘 要 】

Nanobiomaterials based on superhydrophilic vertically-aligned multi-walled carbon nanotubes (VAMWCNT-O2) are promising for their properties and bone tissue biocompatibility. VAMWCNT-O2 films with nanohydroxyapatite (nHAp) aim to improve mechanical properties and biocompatibility of this new nanocomposite due to its resemblance to bone matrix structure. This study aimed to produce in vitro biomineralized nHAp/VAMWCNT-O2 nanocomposites using simulated body fluid (SBF) with two different pHs (6.10 and 7.40) during 7 days to obtain a new surface design with higher crystalinity and better morphology of nHAp/VAMWCANT-O2 nanocomposites. The objective is to obtain biomineralized nanobiomaterials to enable its applicability as "scaffold" to cellular support and consequent bone tissue formation, accelerating the osseointegration. Layer densification has been achieved due to polycrystalline nanoapatites deposition on surface and between the biomineralized nHAp/VAMWCNT-O2 nanocomposites, without any heat treatment. Therefore, through its characteristics and properties these nanocomposite applications can be considered extremely viable for acceleration of in vivo regenerative processes.

【 授权许可】

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