Metallic ions in organs of rats injected with metallic particles of stainless steel 316L and Ti6Al4V alloy

Materials Research

Silvia Helena Giertz²  Beatriz Luci Fernandes²  Carlos Roberto Fernandes¹  Celia Regina Cavichiolo Franco¹ 

[1] ,Pontifical Catholic University of ParanáCuritiba PR ,Brazil

关键词: metallic implants;    particles release;    in vivo test;    Ti6Al4V alloy;    stainless steel 316L;   

DOI  :  10.1590/S1516-14392010000100009

来源: SciELO

【 摘 要 】

Despite the interest in identifying systemic effects caused by the metallic particles released from long term metallic implants in the body, few works support reliable conclusions about the effects of those particles in organs. The aim of the present work is to look for damages in tissues of liver, kidney, lung and heart of rats submitted to injection of Hank's solution contained particles of Ti6Al4V alloy and Stainless Steel 316L, obtained by metal friction. The particles size ranges from 50 to 200 µm for the Ti alloy and from 100 to 500 µm for the 316L. Tissues isolated from the organs after the euthanasia were prepared and analyzed in an optical microscope and Energy Dispersive Spectrometer (EDS). Lesions caused by an inflammatory response such as strange body epithelioid granuloma and giant cells were found in some of the tissues containing yttrium and aluminum.

【 授权许可】

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