Effect of sterilization on the properties of CDHA-OCP-beta-TCP biomaterial

Materials Research

Loreley Morejón-alonso²  Raúl García Carrodeguas²  José Ángel Delgado García-menocal²  José Antonio Alonso Pérez¹  Salvador Martínez Manent¹ 

[1] ,Universidad de La Habana Universidad de La Habana La Habana,Cuba

关键词: octacalcium phosphate;    calcium-deficient hydroxiapatite;    tricalcium phosphate;    sterilization;   

DOI  :  10.1590/S1516-14392007000100005

来源: SciELO

【 摘 要 】

The effect of the method of sterilization on the physical, chemical and mechanical properties of a new bone repairing material was studied. The material was obtained by thermal hydrolysis of beta-tricalcium phosphate/orthophosphoric acid cement and was composed of calcium deficient hydroxyapatite, octacalcium phosphate (OCP), and beta-tricalcium phosphate. Partial decomposition of the OCP was observed after sterilization for the three methods. Decomposition increased to the following sequence of sterilization methods: ethylene oxide; autoclaving; dry oven. On the other hand, mechanical strength decreased with regard to non sterilized material in the sterilization sequence: ethylene oxide; dry oven; autoclaving. The compressive strength was 8.5 ± 1.0; 9.0 ± 1.2; 8.2 ± 0.8 and 6.5 ± 1.0 MPa, whereas diametral tensile strength was 2.1 ± 0.3; 2.5 ± 0.1; 1.9 ± 0.9 and 1.6 ± 0.3 for the material sterilized by ethylene oxide, dry oven, and autoclaving, respectively. Several compositional and microstuctural changes were detected after dry heat and autoclave sterilization. Ethylene oxide sterilization had lesser effect on the chemical composition and strength than dry heat and autoclaving.

【 授权许可】

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