HPMA and HEMA copolymer bead interactions with eukaryotic cells

Materials Research

Cristina D. Vianna-soares²  Kim Cherng-ju¹  Kadriye Ciftci¹  Michael R. Borenstein¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Farmácia Belo Horizonte MG ,Brazil

关键词: cell attachment;    adhesion;    hydrophilic/hydrophobic beads;    acrylate polymer;   

DOI  :  10.1590/S1516-14392004000300016

来源: SciELO

【 摘 要 】

Two different hydrophilic acrylate beads were prepared via aqueous suspension polymerization. Beads produced of a hydroxypropyl methacrylate (HPMA) and ethyleneglycol methacrylate (EDMA) copolymer were obtained using a polyvinyl alcohol suspending medium. Copolymers of 2hydroxyethyl methacrylate (HEMA), methyl methacrylate (MMA) and ethyleneglycol methacrylate (EDMA) beads were obtained using magnesium hydroxide as the suspending agent. Following characterization by scanning electron microscopy (SEM), nitrogen sorption analysis (NSA) and mercury intrusion porosimetry (MIP), the beads were cultured with monkey fibroblasts (COS7) to evaluate their ability to support cell growth, attachment and adhesion. Cell growth behavior onto small HPMA/EDMA copolymer beads and large HEMA/MMA/EDMA copolymer beads is evaluated regarding their hidrophilicity/hidrophobicity and surface roughness.

【 授权许可】

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