Evaluation of the biocompatibility of a new biomembrane

Materials Research

Fatima Mrue²  Joaquim Coutinho Netto¹  Reginaldo Ceneviva²  João José Lachat¹  José Antônio Thomazini¹  Helder Tambelini¹ 

[1] ,University of São Paulo Faculty of Medicine Department of Surgery

关键词: Biomaterial;    biomembrane;    biocompatibility;   

DOI  :  10.1590/S1516-14392004000200010

来源: SciELO

【 摘 要 】

Biocompatibility has been considered one of the most important items to validate a biomaterial for its application in human organisms. The present work evaluates the biocompatibility of a new biomembrane using in vivo assay in different animal species. The experiments to evaluate the cellular reaction were carried out through the implantation of the material into the subcutaneous tissue of animals and the results showed a good reaction of the host tissue without any signal of fibrosis or rejection. The cell adhesion experiments were done by means of the measure of the DNA content on the material surface after its implantation into the subcutaneous tissue of animals and the results showed a growing number of DNA that was proportional to the time of implantation. The healing process was evaluated using a dermal ulcer model and the results showed a good tissue repair resembling a physiologic process. The overall results presented here lead to the conclusion that this new biomembrane is a biocompatible material but more research must be done, as it is a new material desired for medical use.

【 授权许可】

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