Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Revista Brasileira de Plantas Medicinais

G. Negri¹  D. Santi¹  R. Tabach¹ 

[1] ,Federal University of São Paulo Department of Psychobiology São Paulo SP ,Brazil

关键词: Tilia cordata;    HPLC-DAD-ESI-MS/MS;    quercetin and kaempferol glycosides;    tiliroside;    Tilia cordata;    HPLC-DAD-ESI-MS/MS;    glicosídeos de quercetina e canferol;    tilirosideo;   

DOI  :  10.1590/S1516-05722013000200008

来源: SciELO

【 摘 要 】

Tilia species, among which is Tilia cordata Mill. (Tiliaceae), have been used in folk medicine as anxiolytic. The hydroethanolic extract was analyzed by using liquid chromatography with mass spectrometry HPLC-DAD-ESI-MS/MS in negative ion mode, and its chemical composition was compared to flavonoids reported as anxiolytics. The major flavonoids found were: quercetin-3,7-di-O-rhamnoside, kaempferol-3,7-di-O-rhamnoside and kaempferol 3-O-(6"-p-coumaroyl glucoside) or tiliroside. The anxiolytic activity of the genus Tilia has been attributed to the presence of quercetin and kaempferol derivatives, while the anxiolytic activity of T. americana var. Mexicana was attributed to tiliroside, which was also found among the major constituents of this species.

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