Multilocus enzyme electrophoresis typing of Candida albicans populations isolated from healthy children according to socioeconomic background

Revista Brasileira de Epidemiologia

Marcelo Fabiano Gomes Boriollo²  Edvaldo Antônio Ribeiro Rosa¹  Wagner Luis De Carvalho Bernardo²  Denise Madalena Palomari Spolidorio¹  Reginaldo Bruno Gonçalves²  José Francisco Höfling² 

[1] ,State University of Campinas Dental School of Piracicaba Microbiology and Immunology LaboratoryPiracicaba,Brazil

关键词: Candida albicans;    MLEE;    Genetic diversity;    Healthy children;    Socioeconomic category;    Candida albicans;    MLEE;    Diversidade genética;    Crianças saudáveis;    Categoria socioeconômica;   

DOI  :  10.1590/S1415-790X2005000100007

来源: SciELO

【 摘 要 】

The aim of this research was to evaluate the genetic diversity within and between C. albicans populations isolated from the oral cavity of healthy Brazilian children classified into five socioeconomic categories (A to E). Multilocus Enzyme Electrophoresis (MLEE) analysis was the method used to assess genetic diversity. High genetic diversity was observed in all populations that showed predominance of some C. albicans subtypes (Electrophoretic Types - ETs). However, no correlation was observed between a specific ET and a specific population of children. Clustering analysis showed one or more highly related ET clusters, suggesting the existence of indirect and direct propagation routes of C. albicans among healthy children. Microevolutionary changes were observed in some C. albicans populations isolated from children with the same or very similar socioeconomic condition. Furthermore, low transition of C. albicans subtypes can be occurring among certain populations of children coming from high and medium/high, or high and medium/low, or medium/high and medium/low socioeconomic categories, which can also be explained by their own socioeconomic and cultural characteristics.

【 授权许可】

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