Short time L-glutamine supplementation of malnourished rats

Revista de Nutrição

Andréa Ferreira Schuwartz Tannus¹  Márcia Morandi Junqueira-franco¹  Vivian Marques Miguel Suen¹  Guilherme Vannucchi Portari¹  Júlio Sérgio Marchini¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Clínica MédicaRibeirão Preto SP ,Brasil

关键词: amino acids;    dietary supplements;    glutamine;    malnutrition;    nitrogen;    rats;    aminoácidos;    suplementos dietéticos;    glutamina;    desnutrição;    nitrogênio;    ratos;   

DOI  :  10.1590/S1415-52732005000600002

来源: SciELO

【 摘 要 】

OBJETIVE: Considering that in malnourished patients supplemented with L-glutamine the negativity of the nitrogen balance tends to decrease, the present study aimed to determine whether malnourished Wistar rats supplemented with L-glutamine would show lower urinary nitrogen excretion, a greater deposition of nitrogen content in different tissues, and/or an alteration in the plasma amino acid levels. METHODS: The rats were divided into groups: 1) protein-energy malnutrition, 2) protein malnutrition and 3) normally nourished group. The urinary and tissue nitrogen contents were determined by the Kjeldahl method and plasma amino acids by liquid chromatography. RESULTS: Weight, urinary and tissue nitrogen accumulation were significantly reduced in the group with protein-energy malnutrition, but did not improve with L-glutamine supplementation supplied for a short time. The plasma amino acid concentrations showed no special pattern with L-glutamine supplementation. CONCLUSION: It was concluded that it was not possible to detect any positive effect of L-glutamine supplementation on the tissue and urinary nitrogen metabolism in malnourished rats.

【 授权许可】

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