Costs of genetic testing: Supporting Brazilian Public Policies for the incorporating of molecular diagnostic technologies

Genetics and Molecular Biology

Rosane Paixão Schlatter¹  Ursula Matte¹  Carisi Anne Polanczyk¹  Patrícia Koehler-santos¹  Patricia Ashton-prolla¹ 

关键词: molecular diagnosis;    hereditary cancer;    cost analysis;   

DOI  :  10.1590/S1415-475738320140204

来源: SciELO

【 摘 要 】

This study identifies and describes the operating costs associated with the molecular diagnosis of diseases, such as hereditary cancer. To approximate the costs associated with these tests, data informed by Standard Operating Procedures for various techniques was collected from hospital software and a survey of market prices. Costs were established for four scenarios of capacity utilization to represent the possibility of suboptimal use in research laboratories. Cost description was based on a single site. The results show that only one technique was not impacted by rising costs due to underutilized capacity. Several common techniques were considerably more expensive at 30% capacity, including polymerase chain reaction (180%), microsatellite instability analysis (181%), gene rearrangement analysis by multiplex ligation probe amplification (412%), non-labeled sequencing (173%), and quantitation of nucleic acids (169%). These findings should be relevant for the definition of public policies and suggest that investment of public funds in the establishment of centralized diagnostic research centers would reduce costs to the Public Health System.

【 授权许可】

CC BY   
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